Doctoral Researcher

Ihre Aufgaben

The Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus in Frankfurt am Main is an academic non-profit research institute supported by the Federal Ministry of Health and the Ministry for Sciences and Arts of the State of Hessen. The institute is dedicated to basic and translational cancer research in the context of the tumor microenvironment and closely cooperates with the Goethe University Frankfurt and the Frankfurt University Hospital. It provides access to a broad variety of core facilities and an excellent scientific environment.

The LOEWE Center Frankfurt Cancer Institute (FCI) is a research association where interdisciplinary teams work together to elucidate molecular mechanisms of tumor pathogenesis and therapy response to develop innovative targeted therapies.

We are seeking a highly motivated, curious, and proactive Doctoral Researcher who will become a part of the research team headed by Dr. Mélanie Tichet at the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy.

Project description

Your project is centered on characterizing suppressive myeloid cells in the tumor and investigating their role in response to therapy to identify actionable, mechanism-based strategies for their remodeling to facilitate immune attack and anti-tumor responses. You will work with preclinical in vivo models, isolate immune cells in vitro, and perform coculture assays and flow cytometry, among other techniques. Additionally, applicants will participate in weekly lab meetings and journal clubs within the vibrant scientific environment of the GSH.

Our group focuses on identifying and understanding the microenvironment-mediated mechanisms of therapeutic resistance and tumor recurrence by employing a wide array of molecular biology, biochemistry, and in vivo approaches. Our lab aims to identify and comprehend the immunoregulatory mechanisms within the TME that suppress T cell immunity at the cellular and molecular levels to improve therapeutic strategies employing state-of-the-art preclinical in vivo cancer models (melanoma, pancreatic cancer, and glioma).

Ihr Profil

• BSc. or MSc. degree in life sciences or biotechnology

• A strong interest in cancer immunology, previous expertise in cancer research is a plus

• High level of motivation, curiosity, communication, proactivity, and learning skills

• Willing to promote a highly collaborative environment

• Organizational skills and a cooperative attitude

• Your spoken and written English is excellent. English is the working language in the lab and institute.

Wir bieten Ihnen

• Development of a scientific profile

• Integration into structures at the FCI

• Participation in further training and qualification programs

• Support in methodological developments and full guidance

• Stimulating, highly collaborative, and friendly atmosphere

• An outstanding international cancer research environment - with a special emphasis on tumor microenvironment and tumor immunology

• Flexible working hours as part of the good work-and-family life balance

• A salary in accordance with the agreement for the public service of the state of Hesse (E13, 65%) with all the usual social benefits, which is available for 3 years with the option for extension

Interested?

Kontakt

T: +4969-63395-400 Email: m.tichet@georg-speyer-haus.de, Read more about the research of Mélanie Tichet on our website (https://georg-speyer-haus.de/en/staff/tichet-research/)., Applications should be submitted electronically to bewerbung@georg-speyer-haus.de as a single PDF containing a cover letter, a CV, two letters of recommendation (with contact information), and certificates.

For further information, please contact Dr. Melanie Tichet (m.tichet@georg-speyer-haus.de).